摘要
目的：本文报告了７６４－３治疗兔症状性脑血管痉挛的实验结果。方法：通过观察动物在ＳＡＨ前后的神经功能状态变化，ＴＣＤ检测基底动脉血流速度变化及光镜，电镜下基底动脉壁结构的形态学变化，进行每组治疗前后对比及组间比较。结果：局部应用７６４－３组病变最轻，静脉应用７６４－３、尼莫地平组次之，对照组改变最严重。结论：７６４－３具有缓解血管痉挛的作用，其作用在某些方面优于尼莫地平，而局部应用较全身用药效果明显。
Objective: To study the adimissin of 764 3 in different way to treat D CVS(delay cerebral vasospasm). Methods:Animals were divided in to four group:A:764 3 locally, B:764 3 venously, C: nimolipine venously, D:contrast. Neurological deficits observation, TCD, angiography, microscpe and electron microscope were used to determine the effect of 764 3 treating delay CVS. Results: All animals appeared vasospasm, but it was mild in group A, the speed of basil artery flow accelerated and had statisitical significance except group A, Artery wall was found to be damaged sevreely in group D, partialy in B and C and silghtly in A. Conclusion: 764 3 is effective in treating CVS and advantage to nimodipine. It can reduce and postpone CVS and is more effcetive in local using than venoclysis.
出处
《中华神经外科杂志》
CSCD
北大核心
1997年第2期98-101,共4页
Chinese Journal of Neurosurgery
