摘要
目的探讨适合检测儿童幽门螺杆菌(Hp)抗原的方法。方法对2000年9月-2006年2月儿科消化专科门诊及住院937例患儿行13C尿-素呼气试验(13C-UBT)。其中96例行胃黏膜活检标本检测;557例行Hp粪便抗原(HpSA)检查。2003年4月-2004年4月105例患儿同时进行13C-UBT及HpSA检测,以13C-UBT作为诊断标准。结果1.13C-UBT阳性检出率为41.7%,胃镜取胃黏膜活检的Hp抗原阳性检出率40.6%,HpSA的抗原阳性检出率为38.2%,三者间无统计学差异。2.同时行13C-UBT及HpSA患儿105例,13C-UBT阳性率为41.9%,HpSA阳性率为39.0%,以13C-UBT为诊断标准,HpSA检测Hp感染敏感性为91.8%、特异性为81.8%、一致性Kappa系数为0.743(P=0),13C-UBT与HpSA检测阳性检出率无统计学差异(P=0.388)。结论13C-UBT与HpSA 2种检测方法均可作为临床非侵入性检测Hp抗原有效方法,且HpSA更简便、非侵入、经济,是儿童及家长更易接受的诊断儿童Hp感染的有效方法。
Objective To explore the optimal methods to detect helicobacter pylori （Hp） antigen in children. Methods ^13 C labeled urea breath test （ ^13 C - UBT） was performed on 937 children of alimentary department from Sep. 2000 to Feb. 2006. Gastric mucosa biopsy of 96 chil- dren was detected. Hp stool antigen （HpSA） status of the 557 children were evaluated. Both ^13 C - UBT and HpSA were assayed in 105 children from Apr. 2003 to Apr. 2004. Method of ^13 C - UBT was taken as the golden standard on diagnosis of Hp infection. Results Forty - one point seven percent children was positive for ^13 C - UBT. Forty point six percent children was positive for gastric mucosa biopsy. Thirty - eight point two percent was positive for HpSA. The difference was not significant. 2. Among the 105 children performed by both ^13 C - UBT and HpSA, 41.9% was positive for ^13 C - UBT and 39.0% for HpSA. Taking ^13 C - UBT as the golden standard, sensitivity of HpSA to diagnose Hp infection was 91.8% ,and its specificity was 81.8%. Consistency Kappa coefficient was 0. 743（P =0） ,which denoted that there was no significant difference on the positive detection rate between ^13 C - UBT and HpSA （ P = 0.388 ）. Conclusions ^13C - UBT and HpSA as non - invasive technique is effective to detect the Hp antigen. Compared to ^13 C -UBT, as a convenient, noninvasive, economical method, HpSA detection is much more acceptable to children and their patients.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第19期1449-1450,共2页
Journal of Applied Clinical Pediatrics
关键词
螺杆菌
幽门
诊断
儿童
helicobacter pylori
diagnosis
child
