摘要
目的探讨应用NAC治疗对高血压的影响。方法雄性自发性高血压大鼠(n=30),随机分成N-乙酰半胱氨酸组、安慰剂组和基础组三组,基础组入选后即处死留取血标本检测。N-乙酰半胱氨酸组和安慰剂组测量实验前后收缩压,并检测大鼠血清NO含量及白细胞介素1含量。结果实验结束时N-乙酰半胱氨酸组血压明显低于安慰剂组(P<0.05)。N-乙酰半胱氨酸组血浆NO浓度明显高于安慰剂组(P<0.05)。N-乙酰半胱氨酸组白细胞介素1含量低于安慰剂组(P<0.05)。结论大鼠饮用含N-乙酰半胱氨酸(10g/L)自来水能降低血压,提高血浆NO和降低白细胞介素1含量,对大鼠心血管系统有保护作用。
Aim To ascertain whether N-acetylcysteine（NAC） is helpful for hypertension or not.Methods Male spontaneously hypertension rat（SHR） were randomly divided into three groups：placebo group,NAC group,and base group.Rats in the base group were sacrificed before treatment,and blood samples were detected.Syntolic blood pressure（SBP）,nitric oxide（NO）,and interleukin-1（IL-1） was measured in placebo group and NAC group.Results The SBP of placebo group was higher than NAC group after treatment.NO was higher in NAC group than placebo group（P〈0.05）.IL-1 was higher in placebo group than NAC group（P〈0.05）.Conclusion NAC（10 g/L） can step down blood pressure in spontaneously hypertension rat,and has protective effects on it.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第6期443-444,共2页
Chinese Journal of Arteriosclerosis
