摘要
目的探讨福辛普利对中老年2型糖尿病并发高血压患者内皮功能的影响。方法随机抽取42例中老年2型糖尿病并发高血压患者,口服福辛普利片(10～20)mg/d,疗程6个月,并以24例相匹配的健康者为对照。病例组治疗前及治疗后6个月分别测定血栓调节蛋白(Tm)、一氧化氮(NO)、vW因子及血压水平,并采用高分辨率超声检测反应性充血和硝酸甘油介导的肱动脉舒张功能。结果病例组治疗前与对照组相比,血浆Tm和Vw因子水平较高,NO水平较低(P<0.01)。病例组治疗后6个月与治疗前相比,含服硝酸甘油后右肱动脉内径的变化率差别无统计学意义(P>0.05);血浆Tm和vW因子水平降低,血浆NO水平升高,反应性充血引起的右肱动脉内径的变化率升高(P<0.05),收缩压和舒张压降低(P<0.01)。结论福辛普利治疗中老年2型糖尿病并发高血压患者在降低血压的同时,能有效地改善血管内皮依赖性舒张功能,且使血浆Tm和VW因子水平降低、NO水平升高。
To explore the effect of fosinopril on plasma biomarkers of endothelial cell in elderly patients with type 2 diabetes mellitus complicated with hypertension. Methods Fourty-two patients with type 2 diabetes mellitus complicated with hypertension were treated with fosinopril [（10-20）mg/d] for 6 months. Twenty-four matched healthy people were selected as control. Before treatment and after 6 months of treatment, thromodulin （Tin）, von willebrand factor and nitric oxide （NO） as well as systolic pressure （SBP） and diastolic pressure （DBP） were detected. The reactive congestion and nitroglycerin-induced dilation of the right braehial artery were assayed with high-resolution ultrasound. Results After 6 months of treatment in all patients, diameters of braehial artery after taking glyeeryl trinitrate showed no change markedly, but the plasma levels of Tm and vW factor were decreased and NO was increased obviously than those before treatment. The diameter of braehial artery in responding to reactive hyperaemia was improved greatly and the SBP ＆ DBP were all decreased obviously than those before the treatment. Concusion Fosinopril effectively reduces blood pressure and the endothelial-dependent vasodilatation eompanied with decrease of the plasma Tm ＆ vW factor and increase of the plasma NO in patients with type 2 diabetes mellitus complicated with hypertension.
出处
《中国慢性病预防与控制》
CAS
2007年第5期445-447,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
福辛普利
糖尿病
2型
高血压
血栓调节蛋白
一氧化氮
Fosinopril
Type 2 diabetes mellitus
Thromodulin
Niitric oxide
von Willebrand factor
