摘要
用当归等13种中药的丙酮提取液对AFB_1、二氨基芴(2-AF)、亚硝基胍(MNNG)、迭氮钠(NaN_3)等致突变物诱导鼠伤寒沙门氏菌TA98,TA100突变株回复突变抑制作用实验。13个样品中有12个呈不同程度的抑制突变作用(占92.3%);其中分别对2-AF有抑制作用占被测样品的84.6%(TA98),61.5%(TA100);AFB_192.3%(TA98、TA100);MNNG23.1%(TA100);NaN_30.07%(TA100)。提示这些中药可能对预防肝癌有意义,但尚待进一步研究。
Possible antimutation effects of 13 preparations of Chinese Traditional Medicinal Herbs on Salmonella typhimurium TA98 and TA100 mutants were tested.2-AF,AFB_1,MNNG and NaN_3 were used as mutagens. The results showed that 12 of the 13 preparations had different degrees of antimutagenic effect in vitro.84.6% of all preparations showed inhibition effect on 2-AF in TA98 mutant and 61.5% in TA100;92.3% on AFB_1 in TA98 mutant and TA100;23.1% on MNNG in TA100 and 0.07% on NaN_3 in TA100.This experiment may be of some help in the study of Chinese Traditional Medicinal herb resources in the preventive measures against carcinogenesis.
关键词
中药
抗突变
肝癌
预防
Chinese Traditional Medicinal Herbs
Mutation
Antimutation
Chemoprevention of cancer
