摘要
目的制备出盐酸小檗碱纳米乳并对其理化性质进行研究。方法选择油相肉豆蔻酸异丙酯、表面活性剂聚氧乙烯蓖麻油和助表面活性剂甘油,利用伪三元相图制备出盐酸小檗碱纳米乳。用13000r/min,30min离心稳定性和粒径为纳米乳的评价指标,采用HPLC测定纳米乳中盐酸小檗碱的量,同时对该纳米乳的黏度、电导率、折光率、Zeta电位、粒径的基本理化性质和高湿(92.5%)、高温(40℃,60℃)、25℃及强光[(4500±500)lx]的条件下的稳定性进行研究。结果制备出的盐酸小檗碱纳米乳为澄清透明的液体,透射电镜下观察为球状液滴,平均粒径为56.8nm;离心稳定,在上述高湿、高温、强光条件下考察10d,其含药量和粒径均未发生明显变化。结论盐酸小檗碱纳米乳是一种质量稳定的良好药物传递系统。
Objective To prepare berberine hydrochloric nanoemulsion and study its physicochemical characteristics of nanoemulsion. Methods The nanoemulsion components of isopropyl myristate （IPM）, EL40, and glycerin were selected. Berberine hydrochloric nanoemulsion was prepared with pseudoternary phase diagrams. Taking centrifuge tests （13 000 r/min, 30 min） and the average diameter as evaluation indexes of nanoemulsion, the content of berberine hydrochloric in nanoemulsion was determined through HPLC. The basic physicochemical characteristics including viscosity, electric conductivity, refraction, zeta-potentral, and particle diameter were studied. And also the stability of nanoemulsion was studied under the conditions of high humid （92.5%）, high temperature （40 ＇C and 60℃）, and strong light [（4 500± 500） lx]. Results Prepared nanoemulsion was a kind of clarity and transparent solution and it presented as small spherical drops under election microscopy, with the average diameter of about 56.8 nm. Its nanoemulsion for oral application was stable. And also their content and diameter had no distinct change under the above-mentioned conditions. Conclusion The berberine hydrochloric nanoemulsion is good drug delivery system with quality stability. Key words： berberine hydrochloric nanoemulsion; physicochemical characteristics; stability
出处
《中草药》
CAS
CSCD
北大核心
2007年第10期1476-1480,共5页
Chinese Traditional and Herbal Drugs
基金
西北农林科技大学校长基金资助项目(130709)
关键词
盐酸小檗碱
纳米乳
理化性质
稳定性
berberine hydrochloric nanoemulsion
physicochemical characteristics
stability
