摘要
目的:研究用顺铂联合长春新碱(cDDP+VCR,PV)方案治疗恶性妊娠性滋养细胞肿瘤的效果。方法:用PV方案治疗侵蚀性葡萄胎(侵葡)74例、绒毛膜癌(绒癌)40例。第1日VCR 2mg静脉推注,第2日cDDP100mg静脉滴注,同日水化、利尿,第3、4日继续水化、利尿。一个疗程为4d,疗程之间间隔3w。顺铂对肾脏的毒性和呕吐等副作用可用水化、利尿及镇吐药物预防。本组28例在有指征情况下作了子宫切除术(侵葡占17.6%,绒癌占37.5%)。对阴道、肺及脑等处的转移灶也作了相应的处理。结果:对全部病例进行了严密随诊,随诊率99.12%,每例平均治疗2.66个疗程,近期治愈率97.18%(侵葡为98.65%,绒癌为95%)。结论:临床经验证实,该方案具有疗效高、疗程短、方法简便和毒副作用轻等优点,是治疗恶性妊娠性滋养细胞肿瘤的方法之一。
Objective To study on the therapeutic effect of cisdichlorodiaminoplatinum (cDDP) and vincristine (VCR) in patients with malignant gestational trophoblastic tumor. Methods 74 patients with invasive mole and 40 patients with choriocarcinoma were treated with VCR 2rag intravenously on the first day, cDDP 100 mg by intravenous drip on the second day and hydration therapy applied at same time. The hydration therapy was continued on the third and the fourth day. One course lasted for four days and the interval between the courses was three weeks. The nephrotoxity and vomitting as side effects of cDDP might be protected with hydration, diuresis and antivomitory drugs. In addition, hysterectomies were performed in 28 cases indicated (invasive mole 17.6%, choriocarcinoma 37. 5%). The metastatic lesions in vagina, lungs, brain or/and liver, etc, were managed appropriately. Results Careful follow-up was carried out in all patients with a rate of follow-up 99. 12%. The average course of chemotherapy for each patient was 2. 66. The curability in short term was 97. 38% in which invasive mole was 96. 85% and choriocarcinoma 95%. Conclusions The clinical results of this study for follow-up more than six years show that the chemotherapeutic method reported by authors is simple and effective with shorter course and lower toxicity. It is an advantageous alterative for the treatment of malignant gestational trophoblastic tumor.
出处
《现代妇产科进展》
CSCD
1997年第1期33-36,共4页
Progress in Obstetrics and Gynecology
关键词
恶性妊娠性滋养细胞肿瘤
顺铂
长春新碱
Gestational trophoblastic neoplasms
cis-dichiorodiaminoplatinum Vincristine
