摘要
目的总结分析氟尿苷+放线菌素D+依托泊苷+长春新碱(FAEV)化疗方案治疗高危型耐药性妊娠滋养细胞肿瘤的疗效。方法2001年10月至2004年5月,北京协和医院使用FAEV方案治疗高危型耐药性妊娠滋养细胞肿瘤患者共11例,根据国际妇产科联盟(FIGO)预后评分系统(2000年)评分为7～13分(中位数为9分),所有患者均因对其他化疗方案耐药而改用FAEV方案,随诊时间15～42个月。结果以FAEV方案治愈7例患者(64%,7/11);对FAEV方案耐药4例(36%,4/11),其中2例改用其他化疗方案后获得缓解,2例放弃治疗。11例患者共接受FAEV方案化疗64个疗程,FAEV方案的主要毒副反应为骨髓抑制,需使用粒细胞集落刺激因子的疗程占98%(63/64)。结论对于高危型耐药性妊娠滋养细胞肿瘤患者,FAEV化疗方案可作为一种治疗选择。
Objective To evaluate the efficacy of floxuridine, actinomycin D, etoposide, vincristine （FAEV） regimen in treatment of high-risk drug-resistant gestational trophoblastic tumor （GTT）. Methods From October 2001 to May 2004, 11 cases of high-rlsk drug-resistant GrIT were treated with FAEV regimen. The International Federation of Gynecology and Obstetrics （FIGO） prognosis score （2000） was 7 to 13 （median 9）. All patients were referred to Peking Union Medical College Hospital because of failure of chemotherapy previously. After the FAEV treatment, they were followed up for 15 to 42 months. Results Seven cases （64%, 7/11） were cured by FAEV regimen. The median treatment course for serum human chorionic gonadotropin reaching normal level was 3. Four cases （36% , 4/11 ） showed drug-resistant to FAEV regimen. The major side effect of FAEV regimen was myelosuppression. Granulocyte colony stimulating factor support was needed after 98% （63/64） of the courses. Conclusion For those high-risk drug-resistant GTT cases, FAEV regimen could be considered as an effective choice of treatment.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2006年第2期88-90,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠滋养细胞肿瘤
抗药性
肿瘤
抗肿瘤联合化疗方案
Gestational trophoblastic neoplasms
Drug resistance, neoplasm
Antineoplastic combined chemotherapy protocols
