摘要
目的探讨徐州市肠出血性大肠埃希菌(EHEC)O157∶H7(以下简称O157:H7)感染的流行特征,系统观察腹泻患者、宿主动物携带O157∶H7的状况及其与发病的关系,为制定防制策略提供科学依据。方法采用描述流行病学方法对徐州市近8年来O157:H7感染状况与流行特征进行分析。结果1999-2006年徐州共累计报告O157∶H7引起的感染性腹泻并发肾衰竭(HUS)131例,病死率87.79%。徐州市丰县、铜山县发病最多,占全市发病的77.10%。6～9月份为发病高峰,占发病的77.10%。年龄以60岁以上老人为主,占发病总数的74.81%,职业以农民为主,占91.60%。男女性别比例为1∶1.34。腹泻患者、宿主动物带菌率连续性监测结果证实了其与O157:H7感染关系。不同年份O157∶H7毒力基因发生了变化。结论O157∶H7感染自1999、2000年爆发流行后,徐州市疫情一直稳定。尽管疫情发生原因复杂,传播机制不清,但与腹泻患者带菌率、宿主动物带菌率及菌株毒力基因阳性率、毒力基因变迁有关。腹泻患者带菌率、宿主动物带菌率可作为爆发疫情预警监测指标。
Objective This study was to investigate the epidemic characteristics of enterohemorrhagic Escherichio coli （EHEC） O157：H7 infection in the City of Xuzhou, observe the O157：H7 carrying status in diarrhea patients and host animals and its relationship with disease onset, and provide a scientific basis for establishing prevention and control strategies. Methods The O157：H7 infection status and its epidemic characteristics were analyzed by using descriptive epidemiological approaches. Results A total of 131 cases of infectious diarrhea concomitant with renal failure （HUS） caused by O157：H7 were reported in Xuzhou in 1999 and 2006, with a fatality rate of 87.79%. Most of the cases were reported in Feng County and Tongshan County, which accounted for 74.81% of all the cases. The peak period of incidence occurred from June to September with 77.10% of all cases. 77.10% of the patients were old people over 60 years old, and the majority patients were farmers with the percentage of 91.60%. The ratio of male over female was 1：1.34. The diarrhea patients and host animals were verified to be related to O157：H7 infection through continuous surveillance. The virulent gene of O157：H7 varied over different years. Conclusion The infection status of O157：H7 in Xuzhou were kept stable since the outbreaks in 1999 and 2000. It was found out that the epidemic of O157：H7 was associated with the bacteria carrier rate of diarrhea patients and host animals, the positive rate of virulent gene and the variance of the gene, although the epidemic reasons were complex and the transmitting mechanism re- mained unclear. O157：H7 carrier rate of diarrhea patients and host animals could be applied as a surveillance index in epidemic outbreak warning.
出处
《疾病监测》
CAS
2007年第8期516-518,共3页
Disease Surveillance
关键词
大肠杆菌O157∶H7
腹泻病
动物
带菌率
预警监测
Escherichia coli O157：H7
diarrhea disease
host animals
carrier rate
warning surveillance
