摘要
用3%牛磺胆酸钠经胆胰管逆行注射,制成大鼠急性出血坏死性胰腺炎(AHNP)模型,并用丹参进行实验性治疗。结果:模型制作后6小时,对照组胰腺即出现严重的出血坏死及微血管破坏,血清胰酶活性显著升高(P<0.01),12小时后血清胰酶活性呈进行性降低,胰腺微血管及组织学病变则进行性加重;而丹参治疗组24小时时胰腺微血管损害及组织学病变显著改善(P<0.01)。作者认为微循环障碍是加重AHNP后期胰腺病变的重要因素,丹参能改善胰腺的微循环,对AHNP有一定治疗作用。
The model of acut hemorrhagic necrotizing pancreatitis (AHNP) was produced by retrograde injection of 3% sodium taurocholate into the biliopancreatic duct. 48 rats with AHNP were treated with Tanshin by subcutaneous injection(100mg/100g body weight ,q12h ,Tanshin group) ,48 rats with AHNP without any treatment as control (control group). The result showed that in the control group,there were severe hemorrhage, necroses and the lesions of micro vascular, the activity of pancreatic enzyme in serum increased significantly(P<0.01)at 6h,after 12h the activities of those pancreatic enzymes decreased gradually, the lesions of microvascular and histology were becoming severer. In the Tanshin group,at 24h the lesions of microvascular and histology of the pancreas were modified signifi-cantly(P<0. 05). These results suggest that the lesion of microcirculation play an important role in the later AHNP,and Tanshin has some effects on the AHNP by modifying the microcirculation of the pancreas.
关键词
急性
胰腺炎
丹参
微循环
药物疗效
Acute pancreatitis Tanshin Microcirculation Rat
