摘要
目的观察血管内皮生长因子及其受体在单发鼻息内、多发鼻息肉及鼻息肉病中的表达。方法运用免疫组织化学 SP 法检测单发、多发鼻息肉患者各25例和鼻息肉病20例标本中血管内皮生长因子及其受体的表达。结果在不同类型鼻息肉中,血管内皮生长因子及其受体主要在浸润于基质中的不同炎性细胞中表达呈阳性,而且在单发鼻息肉、多发鼻息肉、鼻息肉病中的表达依次增强,其中单发、多发鼻息肉组各分级间,多发鼻息肉组和鼻息肉病组各分级间差异均有统计学意义(P<0.01)。结论血管内皮生长因子及其受体在鼻息肉发病中发挥重要的作用;鼻息肉病在发病机制上异于单发、多发鼻息肉。(中国眼耳鼻喉科杂志,2007,7:282-284)
Purpose To observe the expression of vascular endothelial growth factor （VEGF） and vascular endothelial growth factor receptor 2 （VEGF2） in mono- and poly- rhinopolypus and nasal polyposis. Methods The expression of VEGF and VEGFR2 was detected in 25 cases of mono-rhinopolypus, 25 cases of poly-rhinopolypus and 20 cases of nasal polyposis with immunohistochemistry （SP method）. Results The positive immunostaining for VEGF and VEGFR 2 was found in different inflammatory cells in these tissues to be ranked in the following order： nasal polypsis 〉 poly-rhinopo-lypus 〉 mono-rhinopolypus. Moreover, there was significant difference between groups. Conclusions These findings may support an important role for VEGF and its receptor in the development of nasal polyp and nasal polyposis. The pathogenesis of nasal polyposis is different from that of mono- and poly- rhinopolypus. （ Chin J Ophthalmol and Otorhinolaryngol,2007,7：282-284）
出处
《中国眼耳鼻喉科杂志》
2007年第5期282-284,I0002,共4页
Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词
血管内皮生长因子
血管内皮生长因子受体2
鼻息肉
鼻息肉病
嗜酸性粒细胞
Vascular endothelial growth factor
Vascular endothelial growth factor receptor 2
Nasal polyp
Nasal polyposis
Eosinophil
