摘要
目的：探讨抑肽酶与止血环酸对心脏直视术后出血的影响。方法：６０例风湿性心脏瓣膜病病人拟行首次心脏直视术。随机分成对照组、止血环酸组（总量５ｇ）和抑肽酶组（总量２×１０６ｋＩＵ），试验药于切皮前静脉滴注及加入体外预充液中。测定术中、术后出血量和输血量，术前、术后２４小时血红蛋白、血细胞比容及血小板计数。结果：各试验组与对照组相比，明显减少术后出血量及输血量（Ｐ＜０．０５），抑肽酶组与止血环酸组相比，差别无统计学意义。结论：止血环酸与抑肽酶同样明显减少首次心脏直视术后出血。
Objective:To compare the efficacy of aprotinin with tranexamic acid on postoperative bleeding in cardiac patients operated under cardiopulmonary bypass. Methods:Sixty patients with rheumatic heart disease were schduled for cardiac valvular surgery.They were randomly allocated to control,tranexamic (total 5 g) and aprotinin (total 2×10 6 kIU) groups.Medication was received before skin incision and also added to CPB priming solution.The volume of blood loss and transfusion were recorded during and 24h after operation.Hb,HCT,and platelet count were determined pre and post operatively. Results:Both aprotinin and tranexamic acid provided marked reduction in amounts of postoperative blood loss and transfusion( p <0 05 vs.control).No significant difference was shown between patients treated with either tranexamic acid or aprotinin. Conclusion:Tranexamic acid is as effective as aprotinin on the reduction of postoperative blood loss in patients undergoing direct vision cardiac surgery.
出处
《中国循环杂志》
CSCD
北大核心
1997年第2期88-90,共3页
Chinese Circulation Journal
