摘要
目的：观察体外循环中应用抑肽酶对血小板数及功能的影响。方法：２９例心内直视手术患者，分为Ｉ观察组（ｎ＝１０）预充液中一次性加入国产抑肽酶５万单位／ｋｇ，Ｉ观察组（ｎ＝１０）一次性加入抑肽酶８～１０万单位／ｋｇ，对照组（ｎ＝９）常规预充。３组均观察血小板计数、血小板聚集功能、术后２４小时胸腔引流量和血红蛋白及输血量。结果：术后血小板计数在Ｉ观察组为（１２３．０±３．０）×１０９／Ｌ，显著高于对照组的（９１．５±４．０）×１０９／Ｌ（Ｐ＜０．０５）。血小板聚集功能体外循环中较体外循环前降低，在Ｉ观察组降低不明显与Ｉ观察组和对照组相比较差异显著（Ｐ＜０．０５），术后２４小时胸腔引流量及输血量在ＩＩ观察组较对照组分别减少４２．７％（Ｐ＜０．０５）和４８．１％（Ｐ＜０．０５）。结论：体外循环中应用大剂量国产抑肽酶对术后血小板数及功能均有良好的保护作用，明显减少术后出血及库血的应用。
Objective:To study the effect of aprotinin made in China on platelet count and platelet function. Methods:Twenty nine patients undergoing open heart surgery were divided into three groups:aprotinin group I( n =10),II( n =10)and control group ( n =9).Aprotinin of 50 000 IU/kg and 80 000～ 100 000 IU/kg was given as prime during cardiopulmonary bypass (CPB) for aprotinin group I and II respectively.Platelet count and platelet aggregation,amounts of bleeding and blood transfusion within 24 hours after operation were observed. Results:The platelet count[(123 0±3 0)×10 9/L]of group II was higher than that of control group[(91 5±4 0)×10 9/L, p <0 05]after operation.The platelet aggregation (%) was lower after CPB than before CPB in the control group and group I,while that of group II was not obviously decreased.The amounts of bleeding and blood transfusion of group II were decreased by 42 7% ( p <0 05) and 48 1% ( p <0 05) respectively as compared with the control group. Conclusion:Using large dose of aprotinin made in China during CPB may protect the platelet both in amount and function,and obviously decreases the amounts of bleeding and blood tranfusion postoperatively.
出处
《中国循环杂志》
CSCD
1996年第11期681-683,共3页
Chinese Circulation Journal
关键词
体外循环
抑肽酶
血小板
剂量
Cardiopulmonary bypass
Aprotinin
Platelet (Chinese Circulation Journal,1996,11:681.)
