摘要
原发性肝癌是常见的消化系统恶性肿瘤,其发病率近年有上升趋势。手术切除虽为首选疗法,但仍有15～25%病者因高龄或合并肝硬化而非适应症;采用肝动脉或/和门静脉插管栓塞及化疗,其3年和5年存活率分别仅15%和6%。近年,有报道超声导向经皮对肝癌瘤体内注射无水乙醇(Percutaneous Alcohol
From November 1988 to September 1989, US-guided percutaneous intratumor alcohol injection (PAI) was performed in 41 hepatocellular carcinoma lesions in 14 patients with a tumor diameter between 0.5-12.4cm. There were 12 men and 2 women ranging in age from 28 to 59 years. Six patients had liver cirrhosis and five with lungr metastasis. Among them, either transoatheter arterial embolization, chemotherapy or surgical resection were ineffective because of recurrence or multifocality. No complication occurred after 119 treatments. PAI was given once or twice weekly, up to a maximum of 25 injections, the total amount administered was 109-1206 ml according to lesion diameter, tissue consistency, compliance of the patient and distribution of alcohol inside the lesion. Four cases are still alive after follow-up period of 3,7,8,9 months (?)spectively with a survival rate of 28.75%. Five cases had good responses initially with a short-term survival rate of 35.71% and the remaining cases died of hepatic failure. Serum α-fetoprotein level decreased in nine of these cases. It is considered that PAI may be a valuable treatment for recurrence and late stage hepatocellular carcinoma.
出处
《广东医学》
CAS
CSCD
1990年第5期5-7,15,共4页
Guangdong Medical Journal
