摘要
以鲎试剂定量测定法进行的体内、外实验证实：去芒硝大承气汤、胆盐对ＬＰＳ有直接灭活效应；正常大鼠经口投予大承气汤（ＤＴ）后，其血浆对外加ＬＰＳ灭活能力增强；经口投予ＤＴ于肠源性内毒素血症（ＥＥＴＭ）模型大鼠后，肝组织血流量（ｍｌ／１００ｇ／ｍｉｎ）和肝胆汁流率增加，其肝胆汁对外加ＬＰＳ的灭活能力增强。
In this study, Dachengqi Decoction without Mirabilite and bile salts was observed to have direct inactivating effect on LPS,which was measured by Tachypleus Amebocyte Lysate quantitative test in vitro.when normal rats were administered with DT orally,the inactivating ability of the plasma on LPS was increased.When DT was administered to the model rats with enterogenous endotoxemia(EETM),the heptic regional blood flow(ml/100g/min), bile flow and the bile inactivating ability on LPS has been improved greatly.
出处
《中国实验方剂学杂志》
CAS
1997年第1期15-18,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
大承气汤
方剂
胆盐
内毒素
药理学
Dachengqi Decoction,bile salts,LPS,heptic regional blood flow
