摘要
随着耐药病原菌出现,寻求更为安全有效的新型抗菌制剂迫在眉睫。抗菌肽具有广谱抗菌活性,杀菌快,不易产生耐药性等优点,是理想的新型抗菌剂,具有广阔前景。α-螺旋型抗菌肽是抗菌肽中的一大类。从α-螺旋型抗菌肽螺旋度,疏水力矩,疏水性,净正电荷数等方面阐述了结构与功能关系,及构效关系在α-螺旋抗菌肽分子设计与改造中的应用。
In response to problems from the development of multi-drug-resistant pathogenic bacteria, it is urgent to find new antimicrobials. Antimicrobial peptides （AMPs） are a kind of ideal new antimicrobials with the advantages including their potential for broad-spectrum activity, rapid bactericidal activity and low propensity for resistance development, and have a bright future. Alpha-helical antimicrobial peptides are a main kind of AMPs. The following features was reviewed and elucidated including the structure and activity relationship （SAR） from different aspects including the degree of helicity, hydrophobic moment, hydrophobicity, net positive charges and so on, and the application of SAR on the molecular design and improvement of AMPs.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2007年第9期116-119,共4页
China Biotechnology
基金
国家"863"计划资助项目(2004AA246040)
北京市自然科学基金资助项目(415062031)
关键词
α-螺旋型抗菌肽
结构参数
分子设计与改造
Alpha-helical antimicrobial peptides Structural parameters Molecular design and imprbvement
