摘要
采用ＡＢＣ免疫组织化学方法，检测７２例原发性胃癌ｐ５３表达变化，探讨肿瘤抑制基因ｐ５３蛋白过度表达与胃癌生物学行为的关系。结果ｐ５３阳性染色率为５１．４％（３７／７２），其过度表达与肿瘤浸润深度、淋巴结转移及肿瘤的分化程度呈正相关（Ｐ＜０．０５）。ｐ５３阳性肿瘤淋巴结转移率为８６．０％，ｐ５３阴性肿瘤的淋巴结转移率为６０％，前者明显高于后者（Ｐ＜０．０５）。进一步观察显示ｐ５３过度表达与胃癌的分化程度有明显的相关性，其在高、低分化胃癌中的表达率分别为３９％、７８％，两者差异显著（Ｐ＜０．０５）。结果表明ｐ５３在胃癌发生发展中可能起着重要的作用，检测ｐ５３可作为预后判断的有效指标。
With the immunoperoxidase method(ABC method), the relation between p53 overexpression and biological behauior of 72 cases of primary gastric carcinoma was analyzed and discussed. The results showed that 51.4%(37/72) gastric cancer expressed high level of p53 protein (positive nuclear staining). This overexpression was positively correlated to the status of cancerous infiltration degree, lymph node metastasis and differentiation of gastric cancer ( P <0.05). The lymph node metastasis rate in positive and negative p53 staining gastric carcinoma was 86.0% and 60% respectively. It indicated that the former was higher than the latter ( P <0.05). The futher observation revealed that the rate of p53 overexpression of poorly differentiated gastric cancers (78%) was higher than that of well defferentiated ones(39%). Between them there was significant difference ( P <0.05). These data suggested that p53 overexpression may play an important tole in the genesis and development of gastric cancer and that p53 immunostaining assay may be of great help in the evaluation of prognosis in patients with gastric cancer.
出处
《实用癌症杂志》
1997年第2期87-88,共2页
The Practical Journal of Cancer
关键词
P53蛋白
生物学行为
胃肿瘤
p53 protein Gastric cancer Biological behavior
