摘要
动脉粥样硬化是一个复杂性全身性炎症性过程.病变部位形成粥样斑块,斑块破裂引发血栓形成是导致急性冠脉综合征发生的主要原因.心室重构是慢性心力衰竭的前奏.他汀类药物在动脉粥样硬化的治疗中发挥着越来越重要的作用,除了降脂作用,更具有多效性,包括提高一氧化氮生物利用度、抗炎、抗氧化、稳定动脉粥样硬化、改善心功能等.现就当前他汀类调脂药物作用多效性的主要研究进展作一综述.
Atherosclerosis is a complex systemic inflammation process.Acute coronary syndrome is caused chiefly by atherosclerotic plaque instability.Ventricular remodeling is the early change of chronic heart failure.Statins are playing an increasingly important role in treating atherosclerosis.Besides cholesterol-lowering properties,pleiotropic effects of statins include increasing bioavailability of nitric oxide,anti-inflammation,antioxidant properties,stabilization of atherosclerotic plaques and improvement of cardiac function.This article reviews progress in research into the pleiotropic effects of statins.
出处
《内蒙古民族大学学报（自然科学版）》
2007年第4期447-449,共3页
Journal of Inner Mongolia Minzu University：Natural Sciences
关键词
他汀类
动脉粥样硬化
心室重构
多效性
Statins
Atherosclerosis
Ventricular remodeling
Pleiotropic effects
