摘要
目的:研究鹅绒藤全草水提物和氯仿提取物对小鼠的镇静催眠作用。方法:观察鹅绒藤全草提取物对小鼠正常自主活动的影响,以及对阈下戊巴比妥钠镇静催眠作用的协同作用;采用转轮法测定提取物对小鼠的最小中枢神经系统毒性。结果:腹腔给予鹅绒藤全草提取物对实验小鼠自主活动有剂量依赖性抑制作用;对阈下剂量戊巴比妥钠(30 mg.kg-1,ip)的催眠效应有协同作用,水提物作用的ED50为2.36 g.kg-1,氯仿提取物作用的ED50为0.75 g.kg-1;2种提取物在本实验条件下,未呈现出中枢神经系统毒性。结论:鹅绒藤全草水提物和氯仿提取物对实验小鼠有镇静催眠作用。
Objective： To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice. Method： The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test. Result. the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after iutraperitoueal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2. 36 g . kg ^-1 and 0. 75 g . kg^-1, respectively. Also, both extract-compounds showed no neurotoxicity in the experiment. Conclusion： The extract compounds from C. chinese showed inhibitional effect on CNS.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第17期1774-1776,共3页
China Journal of Chinese Materia Medica
关键词
鹅绒藤
自由活动
镇静催眠
Cynanchum chinese
independent activity
hypnotic effect
