摘要
通过灌胃染毒的方法研究了微囊藻毒素对小鼠抗氧化系统的毒性.结果显示,超氧化物歧化酶活性在第4周升高,过氧化氢酶活性在第3周和第4周下降,表明微囊藻毒素处理后导致H2O2积累,使得氧化损伤加强.谷胱甘肽含量从第2周开始出现明显下降.谷胱甘肽-S-转移酶活性在第4周时发生显著性升高,提示微囊藻毒素和谷胱甘肽结合的速率增高,从而加快了肝组织对微囊藻毒素的清除.本实验结果说明抗氧化系统在微囊藻毒素的解毒方面起到了十分重要的作用.
The toxicity of microcystins on the antioxidant system in mouse liver was investigated. In the present paper, microcystins were administered by garage to mice at a daily dose of 0.2 mg microcystins · kg^-1 body weight for 28 days. The activities of superoxide dismutase increased significantly after 28 days of exposure while catalase decreased at the terminal of exposure. After 7 days, the content of glutathione in liver decreased as compared with control. Glutathione S-transferase activity augmented in treated group compared with the control after 28 days of exposure, suggesting a higher conjugation rate of the toxins with glutathione. These findings suggest that antioxidant system might play an important role in microcystins detoxieation in mice.
出处
《河南师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第3期143-145,共3页
Journal of Henan Normal University(Natural Science Edition)
基金
河南省高校杰出科研人才创新工程项目(2006KYCX021)
河南省动物学省级重点学科经费资助
