摘要
目的对中药白花蛇舌草(Hedyotis diffusaWilld.)化学成分进行分离鉴定。方法采用反复硅胶柱色谱、Sephadex LH-20柱色谱、制备薄层色谱、重结晶等方法进行分离纯化,并通过理化常数测定和光谱数据分析鉴定其化学结构。结果分离得到7个化合物,分别鉴定为β-谷甾醇(β-sitosterol,1)、胡萝卜苷(daucosterol,2)、熊果酸(ursolic acid,3)、2-羟基-3-甲基-1-甲氧基蒽醌(2-hydroxy-3-methyl-1-methoxyanthraquinone,4)、2-羟基-7-甲基-3-甲氧基蒽醌(2-hydroxy-7-methyl-3-methoxyanthraquinone,5)、E-6-O-对甲氧基肉桂酰基鸡屎藤苷甲酯(E-6-O-p-methoxycinnamoyl scandoside methyl ester,6)、E-6-O-香豆酰基鸡屎藤苷甲酯(E-6-O-p-coumaroyl scandoside methyl ester,7)。结论化合物5为首次从该属植物中分离得到。
Objective To study the chemical constituents of Hedyotis diffusa Willd. Methods The com- pounds were isolated by chromatography on silica gel column and identified on the basis of physico-chemical constants and spectral analysis. Results Seven compounds were isolated and their structures were identified as p-sitosterol（ 1 ）, daucosterol （2）, ursolic acid （3）, 2-hydroxy-3-methyl-1-methoxyanthraquinone （4）, 2-hy- droxy-7-methyl-3-methoxyanthraquinone（5）, E-6- O-p-methoxycinnamoyl scandoside methyl ester（6 ）, E- 6-O-p-coumaroyl scandoside methyl ester（7） respectively. Conclusions Compound 5 was obtained from this genus for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2007年第8期479-481,共3页
Journal of Shenyang Pharmaceutical University
关键词
白花蛇舌草
化学成分
结构鉴定
Hedyotis diffusa Willd
chemical consitutents
structure identification
