摘要
目的:探讨叶酸、维生素B6及B12在治疗肾移植患者高同型半胱氨酸(Hcy)血症中的作用。方法:将195例预接受首次肾移植患者随机分为两组:试验组103例,口服叶酸5 mg/d,维生素B650 mg/d及维生素B121 mg/d,连续2个月左右;对照组92例则未口服B族维生素。分别于服药治疗前、术前1 d、术后1、10、20及30 d检测血浆Hcy浓度和血清肌酐水平。结果:试验组血浆Hcy浓度与对照组相比具有统计学意义(P<0.000 1),试验组术后血清肌酐水平下降较快,发生急性排斥反应的比例低于对照组。结论:肾移植患者围手术期适当补充叶酸、维生素B6及B12可降低血浆Hcy浓度,有助于移植肾功能的快速恢复,是减少肾移植并发症及急性排斥反应的重要措施。
Objective： To explore the effect of folic acid, Vit B12, and Vit H12 on hyperhom6cysteinemia in renal-transplant recipients. Methods： 195 renal-transplant recipients were randomly divided into the vitamin treatment group （group A, n = 103, folic acid 5 mg/d, vitamin B6 50 mg/d, B12 1 mg/d, totally 2 months） and the control group （group B, n =92）. The plasma Hcy levels were detemlined before treatment, before operation and 1, 10, 20 and 30 days after operation. Results： The plasma level of Hcy in group B was significantly higher than that in group A before and after operation. The rate of acute rejection was lower in group A than in group B. Conclusion： Vitamin B supplementation can reduce the homocysteine level and the rate of acute rejection for renal-transplant recipients.
出处
《山东大学学报（医学版）》
CAS
北大核心
2007年第8期771-773,777,共4页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金课题(30371302
30471572)
