摘要
目的探讨参附注射液在体外循环手术中对心肌缺血/再灌注损伤的保护作用。方法20例行心脏直视手术的患者,随机分为对照组(C组)和参附注射液组(SF组)。参附组于转机前给予参附注射液2ml/kg。分别于气管插管后(T1)、动脉插管后(T2)、开放主动脉0.5h(T3)、开放主动脉2h(T4)、开放主动脉24h(T5)共5个时间点进行抽血,测定血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、肌酸激酶同工酶MB(CK-MB)、内皮素(ET)和前列环素(PGI2)含量。结果参附组SOD浓度与对照组比较,在T4时间点差异有显著性(P<0.05)。两组病人血浆MDA浓度比较,在T4、T5时间点有统计学意义(P<0.05),参附组比对照组MDA的上升幅度小。两组病人围术期血浆CK-MB和ET浓度在T2时间点之前基本处于正常水平,在T3、T4时间点差异有显著性(P<0.05),参附组CK-MB值于T3、T4时间点较对照组相应时间点低(P<0.05),ET含量在T3、T4时间点参附组明显低于对照组(P<0.05)。参附组与对照组血浆PGI2浓度都于T2时间点达峰值,组间比较在T2时间点参附组PGI2水平高于对照组(P<0.05)。结论在体外循环心脏直视手术中,临床剂量的参附注射液对心肌缺血/再灌注损伤有一定的保护作用。
Objective To explore the protective effects of Shenfu（SF）injection on myocardial ischemia/reperfusion injury in cardiopulmonary bypass（CPB）.Methods Twenty patients undergoing cardiopulmonary bypass heart surgery were randomly divided into two groups：control group（C group,n=10）and Shenfu group（SF group,n=10）.Before CPB,the patients in SF group were treated with SF 2 ml/kg by intravenous injection.The plasma levels of superoxide dismutase（SOD）,maleic dialdehyde（MDA）,creatine kinase isoenzyme MB（CK-MB）,endothelin（ET）and prostaglandin I2（PGI2）were measured after endotracheal intubation（T1）,after aortae intubation（T2）and at 0.5 h（T3）and 2 h（T4）and 24 h（T5）after opening aortae.Results Activity of SOD was higher in SF group than in control group at T4（P〈0.05）.Content of MDA in SF group was significantly lower than those in control group at T4 and T5（P〈0.05）after myocardial ischemia/reperfusion injury.CK-MB and ET levels were normal before T2 in two groups,but lower at T3 and T4 in SF group than in control group（P〈0.05）.Plasma CK-MB level peaked within 0.5 h after reperfusion,and plasma ET level peaked within 2 h after reperfusion.Plasma PGI2 level peaked at T2 and its level was significantly higher in SF group than in control group at same point（P〈0.05）.Conclusion Shenfu injection has protective effects on myocardial ischemia/reperfusion injury in open heart surgery during CPB.
出处
《山西医科大学学报》
CAS
2007年第8期682-685,共4页
Journal of Shanxi Medical University
关键词
心肌缺血
再灌注损伤
参附注射液
体外循环
myocardial ischemia
reperfusion injury
Shenfu injection
cardiopulmonary bypass
