摘要
观察狗心脏停搏30分钟后的心肺复苏效果,以10%氯化钾溶液静脉注射使实验狗心脏停搏、呼吸停止30分钟后,分两组进行心肺复苏实验研究.实验狗每组5只.第一组采用常规法;第二组采用心肺转流(cardiopul-monary bypass,CPB)法.实验期间,定时对心电图、动脉压、静脉压、动脉血气和瞳孔进行监测.心肺骤停后60分钟检查最终复苏效果.结果第一组仅1只狗(20%)于第15分钟后恢复自主循环,瞳孔开始缩小,其余4只狗均未获复苏;第二组于2—3分钟后全部恢复自主循环(100%),瞳孔缩小.复苏30分钟后,其平均动脉压为8—14.0kPa,明显高于第一组(0—12.0kPa)(P<0.05),其静脉压为0.09—0.12kPa,明显低于第一组(0.14—0.24kPa)(P<0.01),PaCO_2为2.06—5.73kPa,明显低于第一组7.22—11.90kPa;PaO_2为21.70一59.81kPa,明显高于第一组(5.88—14.56kPa)(P<0.01).上述实验结果表明,心搏呼吸骤停30分钟后,以心肺转流法进行复苏可有效地恢复自主循环,并可能有益于脑复苏.从少量实验动物复苏效果提示,CPB法明显优于常规法.
To observe the effect of resuscitation by cardiopulmonary bypass (CPB) after 30 minutes cardiac arrest, adult normothermic dogs were submitted to 30 minutes cardiac arrest by potassium chloride induced cardioplegia. Resuscitation was carried out by standard cardiopulmonary resuscitation (CPR) in group I (5 dogs) and by cardiopulmonary bypass (CPB) in group II (5 dogs) for 30 minutes. During resuscitation, ECG, mean arterial blood pressure (MAP), venous pressure (VP), arterial blood gas, pupils were monitored. Only 1 of 5 (20%) in group I, sinus rhythm recovery after 15 minutes,and pupils started to constrict after 20 minutes. However, 5 of 5 (100%) in group II, autocirculation was returned after 2 - 3 minutes and pupils started to constrict to normal after 10 - 20 minutes. In group II, MAP (8. 0-14.0kPa) were significantly higher than that in group I (0 -12.0kPa), VP (93. 0-122. 5×10-3kPa) were significantly lower than that in group I (137. 2 - 235. 2×10-3kPa), PaCO2 were (2. 06-5. 73kPa) significantly lower than that in group I (7. 22 - 11. 90 kPa) and PaO2 (21. 70 - 59. 81 kPa) were significantly higher than that in group I (5- 88-14. 56 kPa) after 30 minutes. Autocirculation returned by CPB for cerebral resuscitation was more effective than by standard CPR after cardiac arrest of 30 minutes in dogs.
出处
《急诊医学》
CSCD
1997年第1期7-9,共3页
关键词
心肺复苏
心肺转流
脑复苏
心脏骤停
Cardiopulmonary resuscitation Cardiopulmonary bypass Cerebral resuscitation.
