摘要
目的:探讨西南地区雌激素受体α(estrogen receptor α,ERα)基因多态性与原因不明月经过少的关系。方法:选择西南地区100名原因不明月经过少患者为实验组,100名月经正常者作为正常对照组。应用分子生物学的方法分析ERα基因1号内含子内切酶PvuⅡ,XbaⅠ限制性片段长度多态性(restriction fragment length polymorphism,RFLP),观察ERα基因多态性基因型在实验组与对照组中的基因型分布。结果:P基因型频率实验组为47.5%,对照组为30.5%(OR=1.810,P=O.012)。X基因型频率实验组为20.5%,对照组为32.0%(OR=0.641,P=0.036);PvuII和XbaI限制性片段长度多态性在两组中均呈多态性分布。结论:ERα基因多态性与原因不明月经过少有关,P等位基因可能是其危险因素;X等位基因可能是其保护因素。
Objective：To investigate the relationship between estrogen receptor alpha （ERα） gene polymorphism and hypomenorrhea of unknown reason in the population of South-western China. Methods： This study included 100 women with hypomenorrhea of unknown reason （experiment group） and 100 women with normal menstruation （control group）. Pvu Ⅱ and Xba I polymorphisms of ERα gene were analyzed by restriction fragment length polymorphism （RFLP） to determine the genotype distribution of ERα gene. Results： The percentages of genotypes P and X were 47.5% and 20.5% in experiment group and 30.5% and 32.0% in control group （OR=1.810,P =0.012;OR=0.641,P = 0.036）. The RFLP of ERα gene in both groups presented polymorphic distribution. Conclusion： ER-α gene polymorphism is associated with hypomenorrhea of unknown reason. P allele may be a dangerous factor and X allele may be a beneficial factor for women with hypomenorrhea of unknown reason.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2007年第4期382-384,共3页
Journal of China Medical University
基金
重庆市卫生局医学科研基金资助项目(06-2-059)
