摘要
目的:分析赤雹果水提取物镇痛作用与阿片受体的关系。方法:采用小鼠浸尾法(45℃)、热板法(48℃)观察赤雹果水提取物(WEFTD)的镇痛作用及纳络酮对其镇痛作用的影响。结果:4.0g/kg WEFTD可显著提高小鼠浸尾法和热板法的痛阈值,与药前比较差异显著(P<0.05),纳络酮+WEFTD组与WEFTD组痛阈值差异无显著意义(P>0.05);纳络酮+吗啡组痛阈显著低于吗啡组(P<0.01)。结论:WEFTD的镇痛作用不是由阿片受体介导的。
Objective：To observe the relationships between the opiate receptor and the analgesic effects of the water extract of Thladiantha Dubia fruits （WEFTD）.Methods：The analgesic effects of WEFTD and the influence of Naloxone were evaluated by tail-immersion test （45℃） and hot-plate test （48 ℃ ）in mice.Results： 4.0g/kg WEFTD could markedly heightened the pain threshold in tail-immersion test and hot-plate test in mice （P 〈 0.05）.There had no significant difference between the pain threshold of 4.0g/kg WEFTD and that of Naloxone＋WEFTD （P 〉 0.05）.The pain threshold obviously diminished in morphine＋Naloxone group than morphine group （P 〈 0.05）.Conclusions：The analgesic effect of WEFTD is not mediated by opiate receptor.
出处
《承德医学院学报》
2007年第3期229-230,共2页
Journal of Chengde Medical University
基金
河北省自然科学基金(C200600863)
河北省中医药管理局资助项目(0332)
关键词
赤雹果
水提取物
镇痛作用
阿片受体
纳络酮
Thladiantha Dubia fruits
Water extract
Analgesic effect
Opiate receptor
Naloxone
