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组织工程化骨软骨复合体的构建

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摘要 传统的治疗关节骨软骨损伤的方法包括自体、同种异体骨软骨柱移植、软骨清除，甚至关节假体置换等，在取得一定成功的同时，也出现了诸如供区继发性受损、免疫排斥、疾病传播及金属假体松动等不足，并且长期疗效不理想。组织工程技术的出现与发展为该类问题的解决提供了一个新途径。现就我们的理解并结合文献，对组织工程化骨软骨复合体的构建的有关方面做一综述。
作者 王双利 查振刚
机构地区 暨南大学第一附属医院骨科
出处 《中华创伤骨科杂志》 CAS CSCD 2007年第8期782-784,共3页 Chinese Journal of Orthopaedic Trauma
基金 广东省科技计划项目（2006815001008） 广州市科技计划项目（200623-E5211）
关键词 骨软骨损伤 组织工程化 复合体 组织工程技术 同种异体骨 假体置换 免疫排斥 假体松动
分类号 R686 [医药卫生—骨科学]
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参考文献17

  • 1Schaefer D, Martin I, Jundt G, et al. Tissue-engineered composites for the repair of large osteochondral defects. Arthritis Rheum, 2002, 46: 2524-2534.
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二级参考文献13

  • 1Buekwaher JA, Mankin HJ. Articular cartilage. PartⅡ : Degeneration and osteoarthrosis, repair, regeneration, and transplantation. J Bone Joint Surg(Am), 1997, 79: 612-632.
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  • 8Adachi N, Sato K, Usas A, et al. Musc:le derived, cell based ex vivogene therapy for treatment of full thickness artecular cartilage detects. J Rheumatol, 2002, 29: 1920-1930.
  • 9Huang Jl, Beanes SR, Zhu M, et al. Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells. Plast Reconstr Surg, 2002, 109: 1033-1041.
  • 10Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mescenchymal stem cells. Science, 1999, 284: 143-147.

共引文献12

中华创伤骨科杂志
2007年 第8期

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