摘要
Laminine(4) is a kind of non-protein amino acids in the kelp,which can prevent and cure hypertension.Because of its trace amount in the nature,it was always prepared by using bio-mimetic synthesis methods.And none or few of the synthetic methods of compound 4 were reported so far.In this article,with lysine(1) as the starting material,compound 4 was prepared with bio-mimetic synthesis method,with a yield of 37.6% and a purity of 97.2%.The structure of compound 4 was determined via HPLC,IR,MS,1H NMR,13C NMR and element analysis,and some of its physical and chemical properties were also studied.The results show that compound 4 is white crystalloid and has no smell,the quasi-molecular ion peak of compound 4 is m/z 207.1,and chemical shift δ 3.63(s,9H),the features at 2945, 2863 and 1480 cm-1 in IR spectrum all show that ε-amino group of compound 4 is fully alkylated.This method could get pure laminine with simple operations,and it could be considered as a green technology with great industrial profits and notable ecological values.
Laminine（4） is a kind of non-protein amino acids in the kelp, which can prevent and cure hypertension. Because of its trace amount in the nature, it was always prepared by using bio-mimetic synthesis methods. And none or few of the synthetic methods of compound 4 were reported so far. In this article, with lysine（1 ） as the starting material, compound 4 was prepared with bio-mimetic synthesis method, with a yield of 37. 6% and a purity of 97. 2%. The structure of compound 4 was determined via HPLC, IR, MS, ^1H NMR, ^13 C NMR and element analysis, and some of its physical and chemical properties were also studied. The results show that compound 4 is white crystalloid and has no smell, the quasi-molecular ion peak of compound 4 is m/z 207.1, and chemical shift 3 3.63（s, 9H）, the features at 2945, 2863 and 1480 cm^-1 in IR spectrum all show that ε-amino group of compound 4 is fully alkylated. This method could get pure laminine with simple operations, and it could be considered as a green technology with great industrial profits and notable ecological values.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第8期1516-1518,共3页
Chemical Journal of Chinese Universities
