摘要
目的探讨自身抗体阴性类风湿关节炎(rheumatoid arthritis,RA)的临床及实验室特点。方法分析247例RA患者,比较自身抗体阴性RA(30例)与抗体阳性RA的临床及实验室特点,以骨关节炎患者(34例)作为对照组。结果自身抗体阴性的RA占12.1%(30/247),自身抗体阴性RA患者的晨僵时间较自身抗体阳性RA患者短(P<0.05);血清免疫球蛋白IgG、IgA及γ球蛋白比率水平显著低于自身抗体阳性RA患者(P<0.01)。而自身抗体阴性RA患者的红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白IgM、γ球蛋白比率均明显高于骨关节炎患者(P<0.05),同时与骨关节炎患者比较,其血红蛋白降低及血小板升高的幅度更明显(P<0.05)。结论RA患者中自身抗体阴性者占12.1%,提示自身抗体阴性RA并不少见。ESR、CRP、免疫球蛋白IgM及γ球蛋白的增高在自身抗体阴性RA的诊断中有参考意义。
Objective To investigate the clinical and laboratory features of auto antibody-negative rheumatoid arthritis （RA）. Method The clinical features and laboratory parameters were compared between auto-antibody-negative （n=30） and-positive （n=217） RA patients. The patients with osteoarthritis （OA, n=34） were used as controls. Results Thirty （12.1%） of 247 RA patients were auto-antibody-negative. It was shown that morning stiffness of the joints in auto-antibody-negative RA was shorter than that of auto-antibody-posi- tive RA patients （P〈0.05）. The levels of IgG, IgA and gamma hemoglobin in auto-antibody-negative RA patients were significantly lower than those in patients with positive antibodies （P〈0.01）. However, as compared with OA patients, auto-antibody-negative RA individuals had higher levels of ESR, CRP, IgM and gamma hemoglobin （P〈0.05）. Conclusions More than 10% RA patients are auto-antibody-negative. ESR, CRP, IgM and gamma hemoglobin are valuable parameters in the diagnosis of auto-antibody-negative RA patients.
出处
《中华风湿病学杂志》
CAS
CSCD
2007年第8期466-468,共3页
Chinese Journal of Rheumatology
关键词
关节炎
类风湿
自身抗体
骨关节炎
Arthritis, rheumatoid
Auto-antibodies
Osteoarthritis
