摘要
为探讨胎脾移植治疗血友病的效果，对5例血友病甲患者施行了胳膊移植术。供你为胎龄为8个月以上的水囊引产死胎，移植物为脾脏连同部分胰腺，供体门静脉、腹腔动脉与受者冒网膜右动、静脉吻合。术后行B型超声波、彩色多普勒、凝血因子（Ⅷ：C）水平监测。结果1例术后21天因陈旧性腹膜后血肿感染死亡，1例失访，1例随访24个月，移植脾增大，Ⅷ：C上升。2例分别于术后6个月、12个月失去功能。研究结果提示术后近期均显一定效果．若能解决排斥等问题，此法可望成为治疗血友病甲的有效方法。
The therapeutic efficacy of fetal splenic transplantation for the treatment of hemophilia A was investigated. The spleen with partial pancreas was taken out from fetal cadavers of 8 or more months after artificial induction of labor by water bag. The celiac artery and portal vein were anastomosed to the right gastroepiploic artery and veins of the recipients. 5 allotransplantation were per formed in 5 cases of severe hemophilia A. All patients were monitored after operation by using B-mode ultrasound, color Duplex scanner and by determination of plasma levels of factor Ⅷ: C. Patient 1 died of infection of remote retroperitoneal hematoma 21 days after the operation and patient 2 failed to finish the follow-up. The patient 3 had enlarged spleen and elevated level of factor Ⅷ: C 24 hours after surgery. Transplants in the remaining two patients lose functions 6 and 12 months, respectively, after transplantation. Our results suggested that if problem of rejection could be resolved, the fetal splenic transplantation would be an effective treatment for hemophilia A.
出处
《中华器官移植杂志》
CAS
CSCD
1997年第1期45-46,共2页
Chinese Journal of Organ Transplantation
关键词
脾移植
血友病
胎脾移植
治疗
Spleen/transplantation Hemophilia Embryo
