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溃疡性结肠炎鼠糖皮质激素受体改变的意义 被引量：2

Change of glucocorticoid receptor in rats with ulcerative colitis
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摘要 目的:探讨鼠溃疡性结肠炎时糖皮质激素(GC)和糖皮质激素受体(GR)的相应改变。方法:Wistar大鼠和C57/L6小鼠共30只,随机分成3组(n=8)进行灌注实验。超速离心鼠肝、胃、结肠组织,取上清液,以3H地塞米松(Dex)为配体,测定动物肝、胃、结肠组织血浆皮质醇及肝、胃、结肠组织GR结合量改变。结果:动物实验组血浆皮质醇明显升高(P<0.05,P<0.01),氢化可的松治疗组血浆皮质醇未继续升高;实验组肝、胃、结肠3H-Dex特异结合位点测定明显降低,治疗组则有所回升(P<0.05,P<0.01)。结论:溃疡结肠炎鼠血浆皮质醇明显升高,提示溃疡结肠炎属应激状态。肝、胃、结肠组织3H-Dex结合量降低,经氢化可的松治疗后肝、胃、结肠组织3H-Dex结合量明显回升,提示血浆皮质醇对GR之作用是正相关作用,为临床合理应用糖皮质激素治疗提供依据。
作者 陈雪萍 陈向芳 邹俊杰 刘志民
机构地区 解放军第 第二军医大学长征医院内分泌科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2007年第7期796-797,共2页 Academic Journal of Second Military Medical University
关键词 结肠炎 溃疡性 受体 糖皮质激素 肝 胃 结肠
分类号 R574.1 [医药卫生—消化系统]
  • 相关文献

参考文献8

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二级参考文献16

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共引文献43

同被引文献26

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引证文献2

二级引证文献1

第二军医大学学报
2007年 第7期

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