摘要
目的观察高血压患者长期口服二氢吡啶类药物对维库溴铵的肌松效应的影响。方法选择长期口服(超过3个月)珍菊降压片或二氢吡啶类药的高血压患者行中下腹部手术各30例,ASAⅠ或Ⅱ级,分为两组:长期口服二氢吡啶类药组(观察组)和长期口服珍菊降压片组(对照组)。用肌松监测仪观察并记录两组患者术中维库溴铵的起效时间(T1消失)、T1出现时间、TOF出现时间、T1恢复至25%的时间及恢复指数。结果两组患者术中维库溴铵的起效时间、作用持续时间和恢复指数差异均无统计学意义。结论高血压患者长期使用二氢吡啶类药物对维库溴铵肌松效应无显著影响。
Objective To investigate the effects of long-term taking dihydropyridines （over three months） on neuromuscular blockade of vecuronium in patients with hypertension. Methods Sixty ASA class Ⅰ or Ⅱ patients undergoing abdomen surgery were divided into two groups with 30 cases each. Control group received zhenju antihypertension tablet orally for more than 3 months,while study group was administered dihydropyridines. The onset time （T1 disappeared）, duration,the time of TOF appeared, the time when T1 returned to 25 % and recovery index of vecuronium were monitored with a peripheral nerve stimulator. Results There were no significant differences in onset time,duration and recovery index between the two groups. Conclusion Dihydropyridines taken for more than 3 months in patients with hypertension have no significant effect on the efficacy of vecuronium.
出处
《临床麻醉学杂志》
CAS
CSCD
2007年第6期457-459,共3页
Journal of Clinical Anesthesiology
