摘要
用叙利亚地鼠胚胎（syrianhamesterembryo，SHE）细胞转化实验研究了G市自来水公司所属的4个水厂的水源水、自来水及2个新拟建的水源点水样有机提取物的细胞毒性和潜在的致癌性。结果：4个采样点的水源水及自来水可不同程度地诱导转化灶的形成，并有一定的细胞毒性；各点自来水的转化率与源水相比有增高的趋势；新拟建的2个水源取水点水样虽有一定的细胞毒性，但无致转化作用。结论：水源水经一般的氯化消毒处理。可增加水中的致突变致癌物质；细胞毒性与遗传毒性并不成平行关系。
PURPOSE Genotoxic activity in raw and drinking water concentrates has been most frequently demon-strated using bacterial mutagenicity tests in vitro. The present study was carry out to examine the potential carcinogenicity and cytotoxicity of raw and drinking water in Syrian hamester embryo (SHE) transformation as-say.METHODS Extracts of water samples were concentrated by adsorption on XAD-2 resin. Cell strain was derived from 11~ 13 day embryos of Syrian golden hamsters.RESULTS The transformation frequencies (TF) of all the samples except for two new locations were high-er than the those of the control culture treated with DMSO, and a dose-response relationship was observed.Comparing to the source water, the response was greater in the chlorinated drinking samples, but both the raw water and treated water including two new site show a certain cytotoxicity.CONCLUSIONS A portion of potential mutagenicity of drinking water attributed to the reaction of chlo-rine used in the disinfection process. Cytotoxicity and potential carcinogenicity were n0t cnsistent.
出处
《上海医科大学学报》
CSCD
1997年第2期107-109,共3页
Journal of Fudan University(Medical Science)
关键词
细胞转化实验
水源水
饮用水
细胞毒性
致癌性
cell transformation
Syrian hamester embryo cell
raw water
drinking water
