摘要
为了探讨γ干扰素（ＩＦＮ－γ）在免疫治疗和免疫化疗中的作用，作者以Ｋ５６２和ＭＫＮ４５人胃癌细胞为靶细胞，观察ＩＦＮ－γ对ＴＩＬ、ＬＡＫ细胞毒活性的影响；同时选用五种化疗药物，以ＳＧＣ７９０１人胃癌细胞为靶细胞，评价ＩＦＮ－γ对化疗药抗癌作用的影响。实验结果表明：（１）ＩＦＮ－γ明显增强ＴＩＬ和ＬＡＫ对两种肿瘤细胞的杀伤活性；（２）ＩＦＮ－γ显著增强五种化疗药物对ＳＧＣ７９０１胃癌细胞的抗癌效应。结果提示，ＩＦＮ－γ作为免疫治疗和免疫化疗的重要免疫调节剂，有一定的应用前景。
We studied the effects of IFN γ in immunotherapy and chemoimmunotherapy.The effects of IFN γ on TIL and LAK cytotoxicities on K562 tumor cell line and MKN45 gastric cancer tumor were observed.The antitumor effects of 5 chemotherapeutic agents with or without IFN γ on SGC7901 gastric cancer cell line were evaluated.The results showed that:(1) IFN γ obviously enhanced the cytotoxicities of TIL and LAK on 2 cell line;(2) IFN γ also increased the antitumor abilities of 5 agents on SGC7901 cell line.The study suggested that IFN γ is useful in immunotherapy and chemoimmunotherapy as an important immunomodulating agent.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第2期89-91,共3页
Chinese Journal of Surgery
关键词
干扰素
抗肿瘤药
抗肿瘤作用
免疫细胞
Interferon type Ⅱ Antineoplastic agents,combind Immunity,cellular
