1型糖尿病患者自身抗体检测的临床研究进展被引量：3

Clinical Research Progress of Autoantibodies in Type 1 Diabetes

导出

摘要胰岛自身抗体与1型糖尿病的发生、发展、治疗及预防密切相关。最重要的几种与胰岛细胞内特殊蛋白对应的抗体是胰岛细胞抗体、谷氨酸脱羧酶抗体、胰岛素自身抗体、蛋白酪氨酸磷酸酶抗体。很多研究已显示,不同类型的糖尿病抗体出现的顺序不同,且预测疾病的价值也不同,胰岛自身抗体的检测可以帮助区分不同种类的糖尿病。在动物中可以通过利用这些抗体的产生来阻止1型糖尿病的发生,而在人类中还未得到相似的结果。另外,抗体检测还可以用于反映1型糖尿病免疫治疗的效果。 Islet cell autoantibodies are strongly associated with the onset development ,treatment and prevention of type 1 diabetes. Several most important antibody corresponding to specific protein in islet cells are. ICA ,GADA ,IAA,IA-2A.Many studys showed that different type of autoantibody has different occuring sequence as well as different value in predicting diseases.Detection of autoantibodies is helpful to identify different types of diabetes.We can inhibit the genesis of type I diabetes through the production of these antoantibodies in animals,but we still have no similar results in human.Otherwise antibody detection can reflect the efficacy of immunotherapy of type I diabetes.

作者杨斌孙桂香

机构地区天津医科大学

出处《医学综述》 2007年第12期944-946,共3页 Medical Recapitulate

关键词 1型糖尿病自身抗体检测临床研究 Type 1 Diabetes Autoantibody Detection Clinical study

分类号 R725.8 [医药卫生—儿科] R587.1 [医药卫生—内分泌]

引文网络
相关文献

参考文献20

1Sabbah E,Savola K,Ebeling T,et al.Genetic Autoimmune and clinical characteristics of childhood and adult onset type 1 diabetes[J].Diabetes Care,2000,23(9):1326-1332.
2Seissler J,Scherbaum WA.Autoimmune diagnostics in diabetes mellitus[J].Clin Chem Lab Med,2006,44(2):133-137.
3Pozzilli P,Di Mario UD.Autoimmune diabetes not requiring insulin at diagnosis(latent autoimmune diabetes of the adult)[J].Diabetes Care,2001,24(8):1460-1467.
4Decochez K,Tits J,Coolens JL,et al.High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age[J].Diabetes Care,2000,23(6):838-844.
5Savola K,Sabbah E,Kulmala P,et al.Autoantibodies associated with type 1 diabetes mellitus persist after diagnosis in children[J].Diabetologia,1998,41(11):1293-1297.
6Hoppu S,Harkonen T,Ronkainen MS,et al.IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type 1 diabetes[J].Clin Exp Immunol,2006,144(1):59-66.
7Eisenbarth GS,Moriyama H,Robles DT,et al.Insulin autoimmunity:prediction/precipitation/prevention type 1A diabetes[J].Autoimmun Rev,2002,1(3):139-145.
8Baker JM,Barriga KJ,Yu L,et al.Prediction of autoantibody positivity and progression to type 1 diabetes:Diabetes Autoimmunity Study in the Young(DAISY)[J].J Clin Endocrinol Metab,2004,89(8):3896-3902.
9Borg H,Marcus C,Sjoblad S,et al.Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age[J].Pediatr Diabetes,2002,3(3):149-154.
10Torn C,Landin-olsson M,Lernmark A,et al.Prognostic factors for the course of βcell function in autoimmune diabetes[J].J Clin Endocrinol Metab,2000,85(12):4619-4623.