摘要
甲基化诱导静止基因(TMS1/ASC)是一新发现的抑癌基因,可编码pyrin区(a pyrin domain,PYD)和引起caspase聚集的caspase聚集区(a caspase recruitment domain,CARD)二种蛋白—蛋白相互作用区,而这二种蛋白区在调节凋亡和免疫反应中均起重要作用,许多含PYD和CARD的蛋白突变与自身免疫性疾病、癌的发生有关,在人的乳腺癌组织中就发现TMS1/ASC基因甲基化而静止。本文将对TMS1/ASC与细胞凋亡、激活caspase、调节核因子-κB(NF-κB)以及与癌发生的关系进行综述。
TMSI/ASC is a new found anti-oncogene, of which the bipartite protein comprising two protein-protein interaction domains, a pyrin（PYD） and a caspase recruitment domain（CARD） plays an important role in regulating apoptosis and immunological reaction. Mutation of many proteins COntaining these domains has close relationship with autoirrmmne diseases and carcinogenesis. We have found the absence of TMS1/ASC expression in human breast cancer because of methylation of TMS1/ASC gene. This review discusses TMS1/ASC about its relationship with cell epoptosis, activation of inflammatory caspases, regulatory factor NF-kappa B, and carcinogenesis.
出处
《医学综述》
2007年第7期485-487,共3页
Medical Recapitulate
基金
山东省中青年科学家基金项目(2005BS02008)
