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匹维溴铵对肠易激综合征患者回盲部肥大细胞的脱粒影响 被引量：3

Degranulation of mast cell in ileocecal colon in patients with IBS after pinaverium bromide treatment
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摘要 目的评价选择性肠道钙离子拮抗剂匹维溴胺对肠易激综合征(Irritable Bowel syndrome,IBS)的临床疗效以及对回盲部肥大细胞脱粒的影响,探讨其治疗IBS的可能机制。方法应用匹维溴胺治疗符合入选标准的IBS患者48例,观察其疗效并检测治疗前后IBS患者回盲部脱颗粒肥大细胞的数目变化。结果匹维溴胺治疗腹泻型IBS疗效明显,治疗前后腹泻型IBS患者脱颗粒肥大细胞数目有显著变化。结论匹维溴胺治疗腹泻型IBS有效,可能抑制了肥大细胞的脱粒活化,机理有待于进一步探讨。 Objective To investigate the curative effect of selective intestinal calcium ion antagonist to irritable bowel syndrome （IBS） and to explore its pharmacological mechanism. Methods Fourty-eight patients with IBS were enrolled in this study by Roma H diagnosis standard. After pinaverium bromide treatment, we evaluated the changes of symptom of the patients with IBS, and counted the number of degranulated mast cells by colonoscopy, biopsies and immunohistochemistry stain of the mast cells in mucosa of ileocecal colon. Results Pinaverium bromide was very effective in patient with diarrhoea-type IBS, and the mast cell numbers with degraulation in ileocecum changed significantly before and after treatment. Conclusion Pinaverium bromide could be a choice for diarrhea-type IBS.
作者 龚锦文 周丽雅 王洁 李江涛 秦荣 周桂霞 孙辉 黄丽
机构地区 九江市第一人民医院消化科 北京医科大学第三医院消化科 九江市第一人民医院病理科
出处 《胃肠病学和肝病学杂志》 CAS 2007年第3期216-218,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 肠易激综合征 肥大细胞 匹维溴胺 Irritable bowel syndrome （IBS） Mast cell （MC） Pinaverium bromide
分类号 R574.62 [医药卫生—消化系统]
  • 相关文献

参考文献9

  • 1Zar S,Kumar D,Kumar D.Role of food hypersensitivity in irritable bowel syndrome[J].Minerva Med,2002,93 (5):403-412.
  • 2O'Sullivan M,Clayton N,Breslin NP,et al.Increased mast cells in the irritable bowel syndrome[J].Neurogastroenterol Motil,2000,12(5):449-457.
  • 3李兆申,董文珠,邹多武,邹晓平,张文俊.肠易激综合征肠粘膜肥大细胞的实验研究[J].解放军医学杂志,2002,27(7):628-630. 被引量：27
  • 4王静,梁列新,张志雄,李国华,钱伟,侯晓华.肠易激综合征患者肠黏膜肥大细胞的变化[J].世界华人消化杂志,2004,12(2):382-384. 被引量：13
  • 5Krishnaswamy G,Kelly J,Johnson D,et al.The human mast cell:functions in physiology and disease[J].Front Biosci,2001,1 (6),D1109-1127.
  • 6Mayer EA,Raybould HE.Role of visceral afferent mechanisms in functional bowel disorders[J].Gastroenterology,1990,99(6):1688-1704.
  • 7Weston AP,Biddle WL,Bhatia PS,et al.Terminal ileal mucosal mast cells in irritable bowel syndrome[J].Dig DisSci,1993,38:1590-1595.
  • 8Gwee KA,Leong YL,Graham C,et al.The role of psychological and biological factors in postinfective gut dysfunction[J].Gut,1999,44(3):400-406.
  • 9Gui XY.Mast cells:A possible link between psychological stress,enteric infection,food allergy and gut hypersensitivityin irritable bowel syndrome[J].J Gastroenterol Hepatol,1998,13 (10):980-989.

二级参考文献20

  • 1杨云生,周殿元,张万岱,张振书,宋于刚.肠易激综合征回盲部肥大细胞的研究[J].中华内科杂志,1997,36(4):231-233. 被引量：47
  • 2Wood JD. Neuropathophysiology of irritable bowel syndrome.J Clin Gastroenterol 2002;35(1 Suppl):S11-22.
  • 3Camilleri M, Heading RC, Thompson WG. Clinical perspectives,mechanisms, diagnosis and management of irritable bowel syndrome. Aliment Pharmacol Ther 2002;16:1407-1430.
  • 4Hasler WL. The irritable bowel syndrome. Med Clin North Am 2002;86:1525-1551.
  • 5Bodemar G, Ragnarsson G. Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis.Lakartidningen 2001;98:666-671.
  • 6Elsenbruch S, Orr WC. Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses. Am J Gastroenterol 2001;96:460-466.
  • 7Hebden JM, Blackshaw E, D'Amato M, Perkins AC, Spiller RC. Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran on transit and symptoms. Am J Gastroenterol 2002;97:2315-2320.
  • 8Chey WY, Jin HO, Lee MH, Sun SW, Lee KY. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol 2001;96:1499-1506.
  • 9Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowelsyndrome. Am J Gastroenterol 2000;95:3503-3506.
  • 10Bouin M, Delvaux M, Blanc C, Lagier E, Delisle MB, Fioramonti J, Bueno L, Frexinos J. Intrarectal injection of glycerol induces hypersensitivity to rectal distension in healthy subjects without modifying rectal compliance. Eur J Gastroenterol Hepatol 2001;13:573-580.

共引文献33

同被引文献26

  • 1杜炜,孟环.肠易激综合征药物治疗的现状和进展[J].胃肠病学,2007,12(5):317-319. 被引量：7
  • 2Spiller R.Clinical Update:Irritable Bowel Syndrome[J].Lancet,2007,369(9573):1586-1588.
  • 3Robert J,Gilkin Jr.The Spectrum of Irritable Bowel Syndrome:a Clinical Review[J].Clinical Therapeutics,2005,27(11):1696-1709.
  • 4Talley N J,Owen B K,Boyce P,et al.Psychological Treatments for Irritable Bowel Syndrome:Acritique of Controlled Treatment Trials[J].Am J Gastroenterol,1996,91(2):277-283.
  • 5Blanchard E B,Lackner J M,Sanders K,et al.A Controlled Evaluation of Group Cognitive Therapy in the Treatment of Irritable Bowel Syndrome[J].Behav Res Ther,2007,45(4):633-648.
  • 6Efskind P S,Bernklev T,Vatn M H.A Double-blind Placebo Controlled Trial with Loperamide in Irritable Bowel Syndrome[J].Scand J Gastroenterol,1996,31:463-468.
  • 7Drossman D A,Toner B B,Whitehead W E,et al.Cognitive-behavioral Therapy Versus Education and Desipramine Versus Placebo for Moderate to Severe Functional Bowel Disorders[J].Gastroenterology,2003,125:19-31.
  • 8Choi S,Park C G,Kim M Y,et al.Action of Imipramine on Activated ATP-sensitive K+ Channels in Interstitial Cells of Cajal from Murine Small Intestine[J].Life Sci,2006,78(20):2322-2328.
  • 9Tabas G,Beaves M,Wang J,et al.Paroxetine to Treat Irritable Bowel Syndrome Not Responding to High-fiber Diet:a Double-blind,Placebo-controlled Trial[J].Am J Gastroenterol,2004,99:914-920.
  • 10Bueno L.Gastrointestinal Pharmacology:Irritable Bowel Syndrome[J].Curr Opin Pharmacol,2005,5:583-588.

引证文献3

二级引证文献18

胃肠病学和肝病学杂志
2007年 第3期

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