摘要
应用光镜、电镜及特殊染色方法对21例糖尿病性肝病的肝穿、手术切除和尸检肝组织进行病理研究。结果:光镜主要变化为核内糖原空洞,脂肪变性、脂肪性肉芽肿及间质纤维组织增生;电镜变化为肝细胞核内染色质呈絮状并中心空虚,胞质有脂肪滴,塘原颗粒增多。线粒体减少、模糊。粗面内质网减少、脱粒。滑面内质网和溶酶体增多,间隙胶元纤维增生。3例进行治疗前后对比,治疗后病变减轻或消失,提示糖尿病性肝病的病理变化是可逆的。肝穿、手术切除及尸检三者组织学改变相同。
21 hepatic tissues obtained from diabetic hepatopathy patients by percutaneous liver biopsy, surgical resection and autopsy were observed under light microscope and electron microscope. Light microscope observation showed that the major changes were glycogen vacuoles in the nuclei, fatty degeneration, fatty granuloma and fibrous regeneration, and elec-tron microscope observation showed cottonoid appearence in the nuclear chromatin of the hepatocytes, vacuoles in the center, fatty droplets in the cytoplasm, an increase in glycogen granules, a decrease in mitochondria with obscure appearence. Other findings included a de-crease in rough endoplasmic reticulum, loss of granules, an increase in smooth endoplasmic reticulum and lysosomes and interstitial collagenofiber regeneration. A comparison of the histological changes before and after treatment was performed in three cases. The results showed that the above mentioned histological changes were milder or even disappeared after treatment, suggesting that the histological changes of diabetic hepatopathy can be reversible. The histological features of the specimens obtained by liver puncture, surgical resection and au-topsy are identical.
出处
《广西医科大学学报》
CAS
1995年第4期492-495,共4页
Journal of Guangxi Medical University
基金
自治区卫生厅课题
关键词
糖尿病
肝病
病理学
diabetics
diabetic hepatopathy
fatty liver
nuclear glycogen
