摘要
本实验以国产ＨＡ涂层烧结的犬用人工股骨柄为研究对象，将行关节置换后的２０只成年犬，按术后３、６、１２、２４、４０周平均分成５个组，全面观察ＨＡ涂层在体内的性能和在负重情况下对假体的固定效果。综合运用了普通光镜、偏振光显微镜、扫描电镜、荧光显微镜来进行组织学观察，发现术后各期ＨＡ涂层都无明显降解，ＨＡ周围无炎性细胞，ＨＡ涂层与钛基底的结合基本良好，ＨＡ外都有骨组织与之紧密结合，并且ＨＡ表面的成骨多集中在股骨的前侧、内侧。ＨＡ表面的部分区域被纤维组织覆盖，且多见于股骨的后侧、外侧。组织计量分析示：术后各期ＨＡ表面骨及纤维膜的占有率分别在６６．４４％～７８％及１６．２２％～１８．５８％之间。影像学示：所有术侧股骨都未见异位骨化、骨皮质反应、骨外膜反应和骨反应线，假体周围都未见透亮线（１例ＨＡ层有碎裂的假体除外）。所有假体周围都有不同程度的皮质骨下新生骨形成。力学测试示：假体上、中、下３段的剪切强度随植入时间的增加而增大，最大剪切强度为３３．０９ＭＰａ，最小剪切强度为０．２８ＭＰａ。本实验表明，用国产ＨＡ涂层来固定人工股骨柄是切实可行的。
In order to observe the properties of the domestic hydroxyapatite (HA) in vivo and the effect of fixation to prosthesis under loading , the authors implanted domestic HA coated hip implants into 20 adult dogs, which were then divided into 5 groups and each group was sacrificed at 3, 6, 12, 24 and 40 weeks after surgery . Histomorphological studies were carried out with light , scanning electron , fluoresence and polarized light microscopes . No degradation was found in the sintered HA coating after surgery . The integration of the interface between HA coating and Ti substrate was solid and the sintered HA coating of the implant formed tight bonding with the surrounding bony tissue in the specimens of different follow-up periods .The apposition of new bone formation on HA surface was most prominent at the anterior and medial aspects of the implant . Histologically, the HA surface was covered by fibrous membrane which was most prominent at the posterior and lateral aspects of the implant. The extent of osteogenesis and the formation of fibrous membrance over the HA surface was different at different follow-up periods .The average coverage of the HA surface by the bony tissue and the fibrous membrane was 66.44%～78% and 16.22～18.54% respectively. No ectopic bone formation was seen on the HA surface . There was no cortical atrophy of the femoral shaft nor bone radiolucent line except in one implant with broken HA coating.Subcortical cancellous bone formation(SCBF) between the implant and the femoral cortex was seen in different degrees in the follow-up period and the incidence of SCBF was 100% at the Gruen zone 4 . The shear strength of the implace increased gradually within 24 weeks after the operation, with a range of 33. 09 MPa to 0.28 MPa . The result of this study strongly demonstrated that the domestric HA material as a coating of the implant could fix the prosthesis effectively .
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1997年第3期155-159,共5页
Chinese Journal of Orthopaedics
