摘要
目的:采用新方法合成罗匹尼罗中间体2-甲基-3-硝基苯乙酸。方法:以2-甲基-3-硝基苯甲醛为原料,采用环合、氧化2步反应进行制备,并用质谱鉴别。结果:制得化合物确证为罗匹尼罗中间体2-甲基-3-硝基苯乙酸,总收率73.6%。结论:本方法简便,且缩短了反应时间,提高了反应收率。
OBJECTIVE： To synthesis （2-methyl-3-nitrophenyl） acetic acid by a new method. METHODS： （2-methyl- 3-nitrophenyl） acetic acid was prepared with 2-methyl-3-nitrobenzaldehyde as raw material by ring closure and oxidation, and the identification was carried out using mass spectra. RESULTS： The prepared compound was ascertained to be （2- methyl-3-nitrophenyl） acetic acid and the total yield was 73.6%, CONCLUSION： The method is simple, due to which, the reaction time has been shortened and the yields has been improved.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第19期1467-1468,共2页
China Pharmacy
