摘要
晚期糖基化终末产物(Advanced glycation endproducts,AGEs)是一类经由糖,包括通过Maillard反应形成的代谢中间产物化学修饰的蛋白。AGEs具有高度交联性。AGE介导的交联蛋白的一个显著特点是降低了溶解度以及减弱了抗蛋白水解的抵抗力。这一作用可引起受累组织生物物理/机械性能的改变,包括强度和刚性的增加。AGE与AGE受体(如RAGE)的相互作用诱导了受体承载细胞核因子-κB(NF-κB)的活化,同时这一作用还诱导了细胞因子、生长因子及黏附分子表达的增加。骨蛋白也会受AGE化学修饰的影响。有研究认为骨蛋白的糖基化修饰影响破骨细胞(骨吸收),成骨细胞(骨形成),以及骨基质(性质及降解)等。
Advanced glycation endproducts （AGEs） are chemical modifications of proteins by carbohydrates including those metabolic intermediates formed during the Maillard reaction. AGEs have a tendency to polymerize. A remarkable feature of AGE-mediated cross-linked proteins is decreased solubility and resistance to proteolytic digestion. This effect results in altered biomechanical properties in affected proteins including increased stiffness and rigidity. The AGE-RAGE interaction additionally induces activation of nuclear factor κB （NF-κB） in RAGE bearing cells. This interaction results in increased expression of cytokines, growth factors and adhesion molecules. Bone proteins are also affected by AGE modification. Investigations support the hypothesis that bone protein glycation influences osteoclasts （bone resorption ）, osteoblasts （bone formation ）, bone matrix （quality and degradation）, and so on.
出处
《中国骨质疏松杂志》
CAS
CSCD
2007年第4期284-287,共4页
Chinese Journal of Osteoporosis
