摘要
晚期糖基化终末产物（AGEs）是碳水化合物以及Maillard反应中形成的代谢中间物，经蛋白质化学修饰后的产物。这些独特化合物是由AGEs受体识别。近来有研究指出骨蛋白也受糖基化修饰的影响。AGEs-AGE受体相互作用通过破骨细胞和成骨细胞核因子-κB途径导致细胞因子、生长因子和黏附分子的表达增加，进而导致骨重建过程紊乱，对骨质疏松发展起重要作用。另外，AGEs参与的骨组织微血管病变可能也是骨质疏松的一个病因。
Advanced glycation end-products （AGEs） are chemical modifications of proteins by carbohydrates including those metabolic intermediates formed during the Maillard reaction. These unique compounds are specifically recognized by AGE receptors. Recent findings provide importance evidence that bone proteins are also affected by AGE modification. AGEs-AGE receptors interaction results in increased expression of cytokines, growth factors and adhesion molecules via osteoclasts and osteoblasts activation of nuclear factor-κB. This interaction could especially contribute to disturbed bone remodeling and be of significant pathophysiologic importance for the development of osteoporosis. AGEs related microangiopathy at the bone tissue is also discussed as a possible reason for osteoporosis. However, the underlying molecular mechanism about osteoporosis remains to be elucidated.
出处
《国际内分泌代谢杂志》
2007年第B04期65-67,共3页
International Journal of Endocrinology and Metabolism
