摘要
目的：观察脂必妥对脑梗死病人血脂及载脂蛋白的影响。方法：脂必妥组３０例（男性１９例，女性１１例；年龄６４±ｓ４ａ）给脂必妥１．０５ｇ，ｐｏ，ｔｉｄ；对照组３０例（男性２０例，女性１０例；年龄６１±５ａ）给烟酸肌醇酯０．４ｇ，ｐｏ，ｔｉｄ；疗程均为１ｍｏ。结果：２组均有显著降低ＴＧ，ＴＣ作用，脂必妥组有显著的降低低密度脂蛋白胆固醇（ＬＤＬ－ｃｈ）及载脂蛋白Ｂ１００（ＡｐｏＢ１００）的作用（Ｐ＜０．０５）及升高高密度脂蛋白及载脂蛋白ＡＩ（ＡｐｏＡＩ）作用，而对照组无上述作用；故ＡｐｏＡＩ／ＡｐｏＢ１００比值脂必妥组显著高于对照组（Ｐ＜０．０５），不良反应见于对照组。结论：脂必妥是较好的降脂药物。
AIM: To compare effects of Zhi-bi-tuo (ZBT) and inositol nicotinate (IN) on blood lipids and apolipoprotein. METHODS: Thirty patients (M 19, F 11; age 64±s 4 a) with cerebral infarction received ZBT tablets 1.05 g(0.35 g/Tab), po, tid, for 1 mo. Another 30 patients (M 20, F 10; age 61±5 a) received IN 0.4 g, po, tid, for 1 mo. RESULTS: Both groups showed decreased serum TC and TG levels. ZBT (but not IN) reduced LDL-ch and apolipoprotein B 100 (Apo B 100 )(P<0.05), and increased HDL-ch, apolipoprotein AI ( Apo AI ) levels; the ratio Apo AI / Apo B 100 was higher in ZBT group than that in IN group ( P < 0.05). Adverse reactions were noted in IN group. CONCLUSION: ZBT is an efficient hypolipidemic agent.
出处
《新药与临床》
CSCD
北大核心
1997年第1期59-61,共3页
关键词
脑梗塞
脂必妥
烟酸肌醇酯
脑梗死
血脂过多
Zhi-bi-tuo
inositol nicotinate
lipoproteins
cerebral infarction
hyperlipidemia
apolipoproteins
