摘要
生物膜是由磷脂双分子层构成的基质和镶嵌或包埋在基质中的蛋白质所组成,脂质体与生物膜结构相似,但一般是热力学不稳定体系,为改善脂质体的稳定性,近年合成和制备了许多不饱和脂质体单体化合物和聚合脂质体。
Polymerizable surfactant,N,N-diethyl-N,N-bis(octadeca-7,9-[or 9,11] dienoyloxyethyl) ammonium bromide has been synthesized by using bleic acid as the starting material. The procedure is as follows: oleic acid is treated by NBS to form allyl bromide. Then the brominated oleic acid is su-bjected to dehydrobromination in the presence of KOH and n-amyl alcohol. Octadecadienoic acid obtained is reacted with PCl3 to form acyl chloride which is esterified with N,N-diethyl-N,N-bis(hy-droxy ethyOammonium bromide at room temperature for 48 h.This new type of polymerizable surfactant may form liposomes under ultrasonic wave irradiation. The average diameter was determined as 600 A by the light scattering technology
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1990年第9期1034-1036,共3页
Chemical Journal of Chinese Universities
基金
国家教育委员会青年教师基金
关键词
脂质体
十八碳二烯酸
季铵盐
Liposome,Octadecadienoic acid, Quaternary ammonium salt
