摘要
目的:通过综述结缔组织生长因子的研究现状,探讨结缔组织生长因子与器官纤维化的关系。资料来源:应用计算机检索美国NCBI PubMed数据库1988-01/2006-12相关结缔组织生长因子与器官纤维化方面的文献,检索词“connective tissue growth factor,fibrosis”,限定文献语言种类为English。资料选择:对资料进行初审,选取包括结缔组织生长因子与器官纤维化的文献,开始查找全文。纳入标准:具有原创性,论点论据可靠的实验文章。观点明确,分析全面的综述文章。文献主体内容与本课题联系紧密的文章。排除标准:具有明显实验设计和结果错误的文章及观点模糊的综述。质量评价主要考察资料的真实性、实施过程是否严密。资料提炼:共检索到336篇关于结缔组织生长因子与器官纤维化的文献,最终纳入32篇符合标准的文献。资料综合:结缔组织生长因子基因是即刻早期基因家族成员,可刺激细胞增殖、分化和凋亡、促进细胞外基质沉积、介导细胞粘附、刺激细胞迁移、促进胚胎发育、损伤修复及新血管的生成。在病理状态下,结缔组织生长因子作为转化生长因子β的下游因子在多种纤维化疾病的发生和发展中起重要作用。文章分别阐明了结缔组织生长因子及其超家族成员、结缔组织生长因子基因和蛋白质结构、受体、功能和生物学作用、致纤维化作用和与其相关的防纤维化策略。结论:通过抑制结缔组织生长因子的表达有望阻断和逆转纤维化进程。
OBJECTIVE： To investigate the association between connective tissue growth factor （CTGF） and organ fibrosis through reviewing the research status of CTGF. DATA SOURCES： Articles about CTGF and fibrosis dated between January 1988 and December 2006 were searched in the computerized online database of American NCBI PubMed with the keywords of ＂connective tissue growth factor, fibrosis＂. STUDY SELECTION; The articles were checked firstly, and only those correlated with CTGF and fibrosis were selected according to the inclusive criteria： ①Original and reliable experimental articles; ②Well analyzed review articles with clear opinions; ③Articles with close relationship with the topic in this paper; and the exclusive criteria： Articles with obvious errors in the experimental design or results and reviews with obscure opinions. Quality evaluation mainly inspected the validity of data and whether the experimental duration was accurate or not. DATA EXTRACTION： Totally 336 articles about CTGF and fibrosis were collected, and 32 were accorded with the inclusive criteria. DATA SYNTHESIS： CTGF gene is one member of the immediate early gene family. It can stimulate cell proliferation, differentiation and apoptosis, promote deposition of extracallular matnx, mediate cell adhesion, stimulate cell migration, accelerate embryonic development, and regulate damage repair and vasculogenesis. In pathologic status, CTGF, as a downstream factor of transforming growth factor 6, plays important roles in the occurrence and development of multiple flbrotic diseases. The selected articles clarify CTGF and its superfamily, the structure of CTGF gene and protein, its receptor, biologic effect, its effect of fibrogenesis and related strategy of anti-fibrosis. CONCLUSION： It is hopeful to block and deteriorate fibrotic process by inhibiting the expression of CTGF.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第23期4610-4613,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
广东省自然科学基金自由申请项目(5000130)~~
