摘要
合成并表征了苯甲醛缩氨基硫脲和３－硝基苯甲醛缩氨基硫脲与Ｃｕ（Ⅱ）、Ｃｏ（Ⅱ）、Ｎｉ（Ⅱ）、Ｚｎ（Ⅱ）、Ｍｎ（Ⅱ）的９个配合物，并用体外试管法测试了配体和配合物的抗癌活性．结果表明，配体ＨＬ１和ＨＬ２是通过亚氨基Ｎ原子和Ｓ原子与过渡金属离子形成配合物，这些配合物的抗癌活性均强于配体，Ｚｎ（Ⅱ）和Ｃｕ（Ⅱ）配合物对腹水癌细胞的杀死率均为１００％
Nine complexes of benzaldehyde thiosemicarbazone(HL 1) and 3 nitrobenzaldehyde thiosemicarbazone(HL 2) with Cu(Ⅱ)、Zn(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)、Mn(Ⅱ) were synthesized and characterized.The anti cancer activities of ligands and complexes were investigated on cancer cell(ascites cancer) in vitro. The results reveal that the transition metal ions are coordinated with HL 1 and HL 2 through the imide N atom and thiocarbonyl S atom to form chelates.All the complexes exhibit the higher antitumor activities as compared with the ligands.For the complexes of copper(Ⅱ) and zinc(Ⅱ) ,the death ratio of cancer cell is 100%.
出处
《西北师范大学学报（自然科学版）》
CAS
1997年第2期48-51,共4页
Journal of Northwest Normal University(Natural Science)
基金
甘肃省教委科研资助
关键词
苯甲醛缩氨基
硫脲
过渡金属配合物
抗癌活性
benzaldehyde thiosemicarbazone3 nitrobenzaldehyde thiosemicarbazonetran
sitionmetal complexanti cancer activity
