摘要
为探讨脾胃虚实证候与胃粘膜细胞凋亡的相关性,采用辨证分型,以胃粘膜细胞凋亡指数(AI)、凋亡基因相关蛋白p53、Bcl-2、Fas等为指标进行研究,结果:①脾胃虚证和实证均表现为胃粘膜AI增加(P<0.05),虚证组高于实证组(P<0.05);②脾胃虚证组和实证组p53、Bcl-2表达高于对照组(P<0.01～0.05);③脾胃实证组Fas表达高于对照组(P<0.05)。说明慢性胃炎从正常到实证到虚证的发展过程中,细胞凋亡逐步增多;p53、Bcl-2、Fas的表达参与细胞凋亡的调控,与证候形成的复杂性有关。
To study the apoptosis and the expression of correlative genes in gastric mucous of chronic superficial gastritis （CSG） with excess and deficiency syndromes of spleen-stomach. With the indexes of syndrome differentiation, apoptosis index （AI）, and correlative genetic proteins such as p53, Bcl-2 and Fas in gastric mucous of CSG with excess or deficiency symdrone of spleen-stomach were studied, and healthy people as control. The results showed that： ① the AI increased in both two syndrome groups （P〈0.05）, and that in deficiency group was higher than excess one （P〈0.05）; ② the expression of p53 and Bcl-2 in the syndrome groups was higher than that in control group （P〈0.05）; ③ the expression of Fas in excess syndrome was higher than that in control group （P〈0.05）. Conclusion： As the pathological changes from normal to the excess syndrome and to deficiency syndrome, the AI increases gradually. The expression of p53, Bcl-2 and Fas take part in the regulation of cell apoptosis, which is one of the mechanisms of the forming of syndromes.
出处
《福建中医学院学报》
2007年第3期1-3,共3页
Journal of Fujian College of Traditional Chinese Medicine
基金
福建省科技三项经费(K02087)
关键词
慢性胃炎
虚证
实证
细胞凋亡
p53
Bcl-2
FAS
chronic superficial gastritis
deficiency syndrome
excess syndrome
apoptosis
p53
Bcl-2
Fas
