摘要
环境中约99.8%的微生物不能用常规的微生物学方法培养,这样就使得绝大部分微生物资源的开发利用受到制约,而宏基因组克隆技术的产生则克服了对不可培养微生物研究的困难。到目前为止,通过宏基因组克隆技术已经获得了许多新的抗生素和酶的基因,而且随着该技术的不断完善将会加大有用分子发现的几率和对复杂微生物群落功能的了解。
It is widely accepted that about 99.8% of the microbe species in the environment can not be cultured by standard methods. Therefore, the absolute majority of microbes in nature have not been studied and utilized. ＂Metagenome technology＂ tries to overcome the bottleneck in the process of the uncultured microbes. Up to now,new antibiotics and enzymes were found by metagenomics cloning. The development of the technology will increase the rate of recovering the useful molecules and understand the functions of the complex microbial communities.
出处
《生物信息学》
2007年第2期86-89,共4页
Chinese Journal of Bioinformatics
关键词
宏基因组
环境总DNA
克隆
筛选
Metagenome
Environmental total DNA
Cloning
Screening
