摘要
[目的]研究甘氨双唑钠对Ⅲ期不可手术非小细胞肺癌(NSCLC)的放射治疗增敏作用。[方法]不可手术的Ⅲ期非小细胞肺癌患者86例随机分为A、B两组,A组接受常规放射治疗加甘氨双唑钠(CMNa);B组接受常规放射治疗。评价近期疗效、1年、2年生存率和毒副作用。[结果]A组的有效率(CR+PR)明显高于B组,分别为63.6%、40.5%(χ2=4.604,P<0.05);而A、B两组的1年、2年生存率无明显差异,前者为61.4%,29.6%;后者为57.1%,26.2%(χ2=0.26,P=0.607)。两组的毒副反应无明显差异。[结论]甘氨双唑钠对Ⅲ期不可手术非小细胞肺癌的放射治疗有增敏作用,可以提高近期疗效,但不能提高长期生存率。
[Purpose] To study the radiosensitizing effect of metronidazole amino acidum natrium （CMNa） on patients with inoperable non-small cell lung cancer（NSCLC） stage Ⅲ. [Methods] Eight-six patients with inoperable stage Ⅲ were randomized divided into group A （CMNa＋radiotherapy） and group B （radiotherapy alone）. The short-term response, the 1-, 2-year survival rates and the toxicity of the two groups were observed. [Results] The response rate （CR＋PR） in group A was significantly higher than that in group B （63.6% vs. 40.5%, X^2=4.604,P〈0.05）. The 1-, 2-year survival rates were 61.4%, 29.6% in group A; 57.1%, 26.2% in group B, without significant difference （X^2=0.26,P=0.607） between the two groups. The toxicity in 2 groups was not significantly different. [Conclusion] CMNa has radiosensitizing effect for patients with inoperable NSCLC stage Ⅲ. Short-term response can be improved, but not long-term survival.
出处
《肿瘤学杂志》
CAS
2007年第3期186-188,共3页
Journal of Chinese Oncology
关键词
癌
非小细胞肺
放射疗法
甘氨双唑钠
放射增敏剂
carcinoma, non-small cell lung
radiotherapy
metronidazole amino acidum natrium
radiosensitizers
