摘要
利用体外培养的视网膜母细胞瘤细胞株及裸小鼠移植瘤模型，研究了巯基修饰剂ＢＳＯ（丁胱亚磺酰亚胺）对其ＧＳＨ（谷胱甘肽）含量的影响以及ＢＳＯ离体放射增敏作用。结果表明，无论是离体还是整体用药，ＢＳＯ均能降低视网膜母细胞瘤的谷胱甘肽含量。离体状态下，ＢＳＯ主要表现出乏氧增敏作用。
The radiobiological effects of thiol modifier BSO on retinoblastoma were studies using cultured retinoblasdtoma cell lines Y--79 and So--Rb 50 and retinoblastoma bearing nude mouse. The preliminary results shown that BSO can deplete intracellular GSH contents of retinoblastoma cells in vitro and vivo. In vitro data demonstrated that lowaand nontoxic concentration BSO increased the retinoblastoma cells radiosensitivity especially under the hypoxic condition.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1995年第1期25-28,共4页
Journal of Radiation Research and Radiation Processing
基金
国家教委资助课题
